UNDERSTANDING GLOBAL CHANGES OF THE MOUSE BRAIN PROTEOME AFTER VAGINAL INFECTION WITH HSV-2 USING A LABEL-FREE SHOTGUN APPROACH

Understanding global changes of the mouse brain proteome after vaginal infection with HSV-2 using a label-free shotgun approach

Herpes simplex virus type 2 (HSV-2) is a common human pathogen that establishes lifelong latency in neurons of the nervous system.The number of severe central nervous system infections caused by the virus has increased recently.However, the pathogenesis of HSV-2 infection in the nervous system is not fully understood.Here, we demonstrated global pr

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Chronic Stress Modulates Interneuronal Plasticity: Effects on PSA-NCAM and Perineuronal Nets in Cortical and Extracortical Regions

Chronic stress has an important impact on the adult brain.However, most of the knowledge on its effects is focused on principal neurons and less on inhibitory neurons.Consequently, recent reports have begun to describe stress-induced alterations in the structure, connectivity and neurochemistry of interneurons.Some of these changes appear to be med

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